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Symbol
Name
ID 		Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Oculomotor apraxia
Spasticity
Cerebral calcification
Basal ganglia calcification
Gliosis
Peripheral demyelination
Abnormal upper motor neuron morphology
Axonal loss
Lateral ventricle dilatation
Hydrocephalus
Ventriculomegaly
Cerebral cortical atrophy
Caudate atrophy
Hypoplasia of the corpus callosum
Cerebral atrophy
Leukoencephalopathy
Apraxia
Chorea
Myoclonus
Babinski sign
EEG abnormality
Abnormality of speech or vocalization
Euphoria
Irritability
Disturbed sensory perception
Lack of insight
Atypical behavior
Inappropriate behavior
Personality changes
Aggressive behavior
Disinhibition
Memory impairment
Dementia
Frontal lobe dementia
Abnormality of movement
Primitive reflex
Gait disturbance
Developmental regression
Seizure
Disease(s) Associated with TYROBP
Nasu-Hakola disease

Mouse Phenotypes
nervous system phenotype
abnormal microglial cell morphology
abnormal oligodendrocyte morphology
abnormal neuron morphology
abnormal axon morphology
abnormal myelination
reduced sensorimotor gating
abnormal excitatory postsynaptic currents
abnormal inhibitory postsynaptic currents
enhanced long-term potentiation
decreased prepulse inhibition
Availability Mouse Genotype
Tyrobptm1.1Viv/Tyrobptm1.1Viv *
Tyrobptm1Ttk/Tyrobptm1Ttk
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory